A master’s thesis discussion was held in the Faculty of Education for Girls at the University of Kufa, entitled (A study of the effect of the drug Lercanidipine on some fetal parameters in pregnant rats).
The thesis submitted by the student (Siham Hadi Ali) from the Department of Life Sciences aimed to reveal the criteria related to pregnant rats during the different stages of pregnancy, including measuring the weights of the livers, brains and kidneys, and studying some biochemical parameters of blood (total protein, albumin, creatinine, urea, antioxidants (glutathione and catalase) and malon Aldehyde) and knowledge of pathological changes in the histological structure of the livers, brains and kidneys.
The thesis concluded that the drug lercanidipine had a negative effect on the weights of the liver, brains and kidneys, and on their histological structure, which belonged to pregnant rats. These effects also increased with the increase in the duration of pregnancy and the concentration of the drug, and that the drug led to adverse effects on the biochemical parameters of blood serum, such as an increase in urea, creatinine, total protein, and albumin during the 7-day stage. of pregnancy and then decreased in the stages of 20 and 16 days of it.
The researcher recommended avoiding the use of drugs as much as possible during the different stages of pregnancy except for extreme necessity and under medical supervision, and searching for safe alternatives to drugs when necessary during the different stages of pregnancy, while not using the drug during pregnancy as a result of structural deformities and tissue effects caused by the drug to fetuses and mothers.