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Preparation and characterization of some heterocyclic compounds from nitrogenous intermediates

Preparation and characterization of some heterocyclic compounds from nitrogenous intermediates
Student / Sarah Mohamed Abdel Alwan, supervised by / Prof. Dr. Hassan Thamer Ghanem
The research included the preparation of some new heterocyclic compounds (five-ring, hexagonal, hept-ring) through three paths.
The first track: – The first track included the preparation of pentagonal heterocyclic compounds through three successive steps.
The first step: Preparing the azo compound (A) by reacting (3-aminoacetophenone) with the base pairing (2-naphthol).
The second step: Preparing the derivatives of the bases of S1, S2, and S3)) by treating the azo compound (A) prepared from the first step with some of the aniline derivatives (4-amino-phenol, 3-nitroaniline, 4-like aniline) respectively.
Third step: Preparation of the amidazolidine derivatives (L1, L2, L3, L4, L5, L6)) through the annular closure of the S1, S2, S3 lipid bases prepared in the second step with the amino acid (clycin and alanine) respectively.
Preparation of tetrazol derivatives (L7, L8) by annular closure of S1 and S2 (S2) bases with sodium azide, respectively.
Due to the importance of heterocyclic compounds in the aforementioned medical, pharmaceutical and industrial fields mentioned in the literature in this research various classes of organic compounds have been prepared, including: –
1- Azo compound.
2- SHF rules.
3- Penta-ring heterocyclic compounds.
4- Hexagonal ring compounds are heterogeneous.
5- Heterocyclic compounds.
Conclusions
  1. The necessity to adhere to the reaction conditions, such as temperature, acidic function, and addition process when preparing azo compounds.
  2. The difference in time periods of the prepared compounds, and this mainly depends on the effect of the driving groups and the pulling groups present in the interaction mediators and amine derivatives.
  3. The possibility of preparing different derivatives of a 1,3-oxazepine ring from the reaction of lipid bases with various anhydrous acids by the mechanics of cyclic addition (7 = 2 + 5).

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